T  1  relaxation time at 0.2 Tesla for monitoring regional hyperthermia: Feasibility study in muscle and adipose tissue | Zendy

Peller Michael | Zendy; Reinl Herbert M. | Zendy; Weigel Andreas | Zendy; Meininger Martin | Zendy; Issels Rolf D. | Zendy; Reiser Maximilian | Zendy

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T 1 relaxation time at 0.2 Tesla for monitoring regional hyperthermia: Feasibility study in muscle and adipose tissue

Author(s) -

Peller Michael,

Reinl Herbert M.,

Weigel Andreas,

Meininger Martin,

Issels Rolf D.,

Reiser Maximilian

Publication year - 2002

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.10155

Subject(s) - adipose tissue , hyperthermia , in vivo , imaging phantom , ex vivo , muscle tissue , breakpoint , magnetic resonance imaging , biomedical engineering , nuclear magnetic resonance , nuclear medicine , materials science , medicine , chemistry , biology , anatomy , radiology , physics , chromosomal translocation , microbiology and biotechnology , biochemistry , gene

The purpose of this study was to characterize T 1 , particularly in the hyperthermia temperature range (ca. 37–44°C), in order to control regional hyperthermia with MR monitoring using 0.2 Tesla, and to improve T 1 mapping. A single‐slice and a new multislice “T One by Multiple Read‐Out Pulses” (TOMROP) pulse sequence were used for fast T 1 mapping in a clinical MRI hyperthermia hybrid system. Temporal stability, temperature sensitivity, and reversibility of T 1 were investigated in a polyamidacryl gel phantom and in samples of muscle and adipose tissues from turkey and pig, and verified in patients. In the gel phantom a high linear correlation between T 1 and temperature ( R 2 = 0.97) was observed. In muscle and adipose tissue, T 1 and temperature had a linear relationship below a breakpoint of 43°C. Above this breakpoint muscle tissue showed irreversible tissue changes; these effects were not visible in adipose tissue. The ex vivo results were confirmed in vivo under clinical conditions. T 1 mapping allows the characterization of hyperthermia‐related tissue response in healthy tissue. T 1 , in combination with fast mapping, is suitable for controlling regional hyperthermia at 0.2 T within the hybrid system. Magn Reson Med 47:1194–1201, 2002. © 2002 Wiley‐Liss, Inc.

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