Proton  T  2  relaxation study of water, N‐acetylaspartate, and creatine in human brain using Hahn and Carr‐Purcell spin echoes at 4T and 7T | Zendy

Michaeli Shalom | Zendy; Garwood Michael | Zendy; Zhu XiaoHong | Zendy; DelaBarre Lance | Zendy; Andersen Peter | Zendy; Adriany Gregor | Zendy; Merkle Hellmut | Zendy; Ugurbil Kamil | Zendy; Chen Wei | Zendy

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Proton T 2 relaxation study of water, N‐acetylaspartate, and creatine in human brain using Hahn and Carr‐Purcell spin echoes at 4T and 7T

Author(s) -

Michaeli Shalom,

Garwood Michael,

Zhu XiaoHong,

DelaBarre Lance,

Andersen Peter,

Adriany Gregor,

Merkle Hellmut,

Ugurbil Kamil,

Chen Wei

Publication year - 2002

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.10135

Subject(s) - phosphocreatine , nuclear magnetic resonance , dephasing , creatine , chemistry , relaxation (psychology) , spin echo , proton , carr , physics , condensed matter physics , magnetic resonance imaging , nuclear physics , energy metabolism , biology , medicine , ecology , biochemistry , radiology , endocrinology , neuroscience

Carr‐Purcell and Hahn spin‐echo (SE) measurements were used to estimate the apparent transverse relaxation time constant ( T † 2 ) of water and metabolites in human brain at 4T and 7T. A significant reduction in the T † 2values of proton resonances (water, N‐acetylaspartate, and creatine/phosphocreatine) was observed with increasing magnetic field strength and was attributed mainly to increased dynamic dephasing due to increased local susceptibility gradients. At high field, signal loss resulting from T † 2decay can be substantially reduced using a Carr‐Purcell‐type SE sequence. Magn Reson Med 47:629–633, 2002. © 2002 Wiley‐Liss, Inc.

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