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Imaging the changes in renal T 1 induced by the inhalation of pure oxygen: A feasibility study
Author(s) -
Jones Richard A.,
Ries Mario,
Moonen Chrit T.W.,
Grenier Nicolas
Publication year - 2002
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10127
Subject(s) - chemistry , kidney , renal cortex , oxygen , inhalation , nuclear magnetic resonance , lung , blood flow , kidney cortex , cortex (anatomy) , renal blood flow , nuclear medicine , medicine , anatomy , physics , biology , neuroscience , organic chemistry
The effect of the inhalation of pure oxygen on the kidney was evaluated by measuring monoexponential T 1 and T * 2relaxation times in nine volunteers using a multiple‐shot turbo spin echo and multiple echo gradient echo sequences, respectively. The T 1 of the renal cortex decreased significantly when breathing pure oxygen as compared to normoxia (from 882 ± 59 to 829 ± 70 msec, P < 0.05), while that of the renal medulla was unchanged. No significant changes were seen in the T * 2of either compartment. Dynamic imaging using an inversion recovery sequence with an optimized inversion time typically produced signal changes of 20% in the renal cortex. Studies to assess if oxygen‐induced changes in flow contributed to this effect showed that the flow contribution was not significant. Although longer inversion times (880 ms) produced optimal contrast, acceptable contrast was also obtained at shorter inversion times (450 msec) in the renal cortex, spleen, and lung, with the latter being of opposite polarity to the other two tissues, implying a shorter parenchymal T 1 than previously reported in the literature. The results are consistent with oxygen acting as an intravascular contrast agent which induces a shortening of T 1 in the arterial blood volume. Magn Reson Med 47:728–735, 2002. © 2002 Wiley‐Liss, Inc.