Premium
Evaluation of four postprocessing methods for determination of cerebral blood volume and mean transit time by dynamic susceptibility contrast imaging
Author(s) -
Perkiö Jussi,
Aronen Hannu J.,
Kangasmäki Aki,
Liu Yawu,
Karonen Jari,
Savolainen Sauli,
Østergaard Leif
Publication year - 2002
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10126
Subject(s) - mean transit time , cerebral blood flow , perfusion , monte carlo method , impulse (physics) , cerebral blood volume , transit time , blood volume , perfusion scanning , biomedical engineering , impulse response , nuclear medicine , mathematics , medicine , physics , radiology , mathematical analysis , anesthesia , statistics , transport engineering , quantum mechanics , engineering
Four different postprocessing methods to determine cerebral blood volume (CBV) and contrast agent mean transit time (MTT) by dynamic susceptibility contrast (DSC) MRI were compared. CBV was determined by two different methods that integrate tracer concentration–time curves numerically and by two other methods that take recirculation into account. For the two methods that use numerical integration, one method cuts the integration after the first pass while the other method integrates over the whole time series. For the two methods that account for recirculation, one method uses a gamma‐variate fit, whereas the other method utilizes tissue impulse response. All four methods determine MTT as the ratio of CBV and cerebral blood flow (CBF). In each case, CBF was obtained as the height of the impulse response obtained by deconvolving the tissue concentration–time curves with a noninvasively determined arterial input function. Monte Carlo simulations were performed to determine the reliability of the methods and the validity of the simulations was supported by observation of similar trends in 13 acute stroke patients. The method of determining CBV and subsequently MTT was found to affect the measured value especially in areas where MTT is prolonged, but had no apparent effect on the visually determined hypoperfusion volumes. Magn Reson Med 47:973–981, 2002. © 2002 Wiley‐Liss, Inc.