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Combined MR proton lung perfusion/angiography and helium ventilation: Potential for detecting pulmonary emboli and ventilation defects
Author(s) -
Zheng Jie,
Leawoods Jason C.,
Nolte Mark,
Yablonskiy Dmitriy A.,
Woodard Pamela K.,
Laub Gerhardt,
Gropler Robert J.,
Conradi Mark S.
Publication year - 2002
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10091
Subject(s) - medicine , perfusion , ventilation (architecture) , lung , ventilation perfusion mismatch , radiology , perfusion scanning , angiography , parenchyma , nuclear medicine , occlusion , airway , cardiology , pathology , anesthesia , mechanical engineering , engineering
Abstract Three‐dimensional (3D) perfusion imaging allows the assessment of pulmonary blood flow in parenchyma and main pulmonary arteries simultaneously. MRI using laser‐polarized 3 He gas clearly shows the ventilation distribution with high signal‐to‐noise ratio (SNR). In this report, the feasibility of combined lung MR angiography, perfusion, and ventilation imaging is demonstrated in a porcine model. Ultrafast gradient‐echo sequences have been used for 3D perfusion and angiographic imaging, in conjunction with the use of contrast agent injections. 2D multiple‐section 3 He imaging was performed subsequently by inhalation of 450 ml of hyperpolarized 3 He gas. The MR techniques were examined in a series of porcine models with externally delivered pulmonary emboli and/or airway occlusions. With emboli, perfusion deficits without ventilation defects were observed; airway occlusion resulted in matched deficits in perfusion and ventilation. High‐resolution MR angiography can unambiguously reveal the location and size of the blood emboli. The combination of the three imaging methods may provide complementary information on abnormal lung anatomy and function. Magn Reson Med 47:433–438, 2002. © 2002 Wiley‐Liss, Inc.