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Imaging cortical association tracts in the human brain using diffusion‐tensor‐based axonal tracking
Author(s) -
Mori Susumu,
Kaufmann Walter E.,
Davatzikos Christos,
Stieltjes Bram,
Amodei Laura,
Fredericksen Kim,
Pearlson Godfrey D.,
Melhem Elias R.,
Solaiyappan Meiyappan,
Raymond Gerald V.,
Moser Hugo W.,
van Zijl Peter C.M.
Publication year - 2002
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10074
Subject(s) - diffusion mri , fiber tract , neuroscience , tracking (education) , anatomy , magnetic resonance imaging , biology , medicine , psychology , radiology , pedagogy
Diffusion‐tensor fiber tracking was used to identify the cores of several long‐association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto‐occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X‐linked adrenoleukodystrophy) was demonstrated. Magn Reson Med 47:215–223, 2002. © 2002 Wiley‐Liss, Inc.