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Assessment of hepatic perfusion parameters with dynamic MRI
Author(s) -
Materne R.,
Smith A.M.,
Peeters F.,
Dehoux J.P.,
Keyeux A.,
Horsmans Y.,
Van Beers B.E.
Publication year - 2002
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10045
Subject(s) - perfusion , blood flow , liver perfusion , bolus (digestion) , nuclear medicine , gadolinium , dynamic contrast enhanced mri , medicine , magnetic resonance imaging , perfusion scanning , intravenous bolus , chemistry , radiology , organic chemistry
Quantification of hepatic perfusion parameters greatly contributes to the assessment of liver function. The purpose of this study was to describe and validate the use of dynamic MRI for the noninvasive assessment of hepatic perfusion parameters. The signal from a fast T 1 ‐weighted spoiled gradient‐echo sequence preceded by a nonslice‐selective 90° pulse and a spoiler gradient was calibrated in vitro with tubes filled with various gadolinium concentrations. Dynamic images of the liver were obtained after intravenous bolus administration of 0.05 mmol/kg of Gd‐DOTA in rabbits with normal liver function. Hepatic, aortic, and portal venous signal intensities were converted to Gd‐DOTA concentrations according to the in vitro calibration curve and fitted with a dual‐input one‐compartmental model. With MRI, hepatic blood flow was 100 ± 35 mL min ‐1 100 mL ‐1 , the arterial fraction 24 ± 11%, the distribution volume 13.0 ± 3.7%, and the mean transit time 8.9 ± 4.1 sec. A linear relationship was observed between perfusion values obtained with MRI and with radiolabeled microspheres ( r = 0.93 for hepatic blood flow [ P < 0.001], r = 0.79 for arterial blood flow [ P = 0.01], and r = 0.91 for portal blood flow [ P < 0.001]). Our results indicate that hepatic perfusion parameters can be assessed with dynamic MRI and compartmental modeling. Magn Reson Med 47:135–142, 2002. © 2002 Wiley‐Liss, Inc.