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Assessment of a single‐acquisition imaging sequence for oxygen‐sensitive 3 He‐MRI
Author(s) -
Deninger A.J.,
Eberle B.,
Bermuth J.,
Escat B.,
Markstaller K.,
Schmiedeskamp J.,
Schreiber W.G.,
Surkau R.,
Otten E.,
Kauczor H.U.
Publication year - 2002
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10032
Subject(s) - monte carlo method , breathing , histogram , hyperpolarization (physics) , nuclear medicine , oxygen , nuclear magnetic resonance , biomedical engineering , chemistry , computer science , physics , medicine , mathematics , artificial intelligence , nuclear magnetic resonance spectroscopy , statistics , organic chemistry , image (mathematics) , anatomy
MRI of the lungs using hyperpolarized helium‐3 ( 3 He) allows the determination of intrapulmonary oxygen partial pressures ( p O2 ). The need to separate competing processes of signal loss has hitherto required two different imaging series during two different breathing maneuvers. In this work, a new imaging strategy to measure p O2 by a single series of consecutive scans is presented. The feasibility of the method is demonstrated in three healthy human volunteers. Maps and histograms of intrapulmonary p O2 are calculated. Changes in the oxygen concentration of the inhaled gas mixture are well reproduced in the histograms. Monte Carlo (MC) simulations of the temporal evolution of 3 He hyperpolarization within the lungs were performed to evaluate the accuracy of this measurement technique, and its limitations. Magn Reson Med 47:105–114, 2002. © 2002 Wiley‐Liss, Inc.