19 F‐MRI of perflubron for measurement of oxygen partial pressure in porcine lungs during partial liquid ventilation | Zendy

LaukemperOstendorf Simone | Zendy; Scholz Alexander | Zendy; Bürger Katja | Zendy; Heussel Claus P. | Zendy; Schmittner Marc | Zendy; Weiler Norbert | Zendy; Markstaller Klaus | Zendy; Eberle Balthasar | Zendy; Kauczor HansUlrich | Zendy; Quintel Michael | Zendy; Thelen Manfred | Zendy; Schreiber Wolfgang G. | Zendy

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19 F‐MRI of perflubron for measurement of oxygen partial pressure in porcine lungs during partial liquid ventilation

Author(s) -

LaukemperOstendorf Simone,

Scholz Alexander,

Bürger Katja,

Heussel Claus P.,

Schmittner Marc,

Weiler Norbert,

Markstaller Klaus,

Eberle Balthasar,

Kauczor HansUlrich,

Quintel Michael,

Thelen Manfred,

Schreiber Wolfgang G.

Publication year - 2002

Publication title -

magnetic resonance in medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.696

H-Index - 225

eISSN - 1522-2594

pISSN - 0740-3194

DOI - 10.1002/mrm.10008

Subject(s) - partial pressure , oxygen , ventilation (architecture) , nuclear magnetic resonance , chemistry , nuclear medicine , materials science , medicine , physics , thermodynamics , organic chemistry

A method for in vivo measurement of oxygen partial pressure (pO2) in porcine lungs during partial liquid ventilation (PLV) with perflubron (PFOB) was developed. A pulse sequence for high‐resolution MRI of the distribution of PFOB in the lung after intratracheal administration was developed as well. Moreover, quantitative measurements of longitudinal relaxation time T 1 of 19 F resonances for assessment of regional pO2 are described. Due to the need to acquire data during a single expiratory breathhold, only low SNRs were achieved in vivo. Therefore, simulations were performed to investigate the influence of background noise on T 1 values calculated from data with low SNR. Based on these simulations, a postprocessing strategy was developed to correct for systematic errors by background noise prior to quantitative analysis. Results of a pilot study in pigs under conditions of PLV are presented. Magn Reson Med 47:82–89, 2002. © 2002 Wiley‐Liss, Inc.

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