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19 F‐MRI of perflubron for measurement of oxygen partial pressure in porcine lungs during partial liquid ventilation
Author(s) -
LaukemperOstendorf Simone,
Scholz Alexander,
Bürger Katja,
Heussel Claus P.,
Schmittner Marc,
Weiler Norbert,
Markstaller Klaus,
Eberle Balthasar,
Kauczor HansUlrich,
Quintel Michael,
Thelen Manfred,
Schreiber Wolfgang G.
Publication year - 2002
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/mrm.10008
Subject(s) - partial pressure , oxygen , ventilation (architecture) , nuclear magnetic resonance , chemistry , nuclear medicine , materials science , medicine , physics , thermodynamics , organic chemistry
A method for in vivo measurement of oxygen partial pressure (pO2) in porcine lungs during partial liquid ventilation (PLV) with perflubron (PFOB) was developed. A pulse sequence for high‐resolution MRI of the distribution of PFOB in the lung after intratracheal administration was developed as well. Moreover, quantitative measurements of longitudinal relaxation time T 1 of 19 F resonances for assessment of regional pO2 are described. Due to the need to acquire data during a single expiratory breathhold, only low SNRs were achieved in vivo. Therefore, simulations were performed to investigate the influence of background noise on T 1 values calculated from data with low SNR. Based on these simulations, a postprocessing strategy was developed to correct for systematic errors by background noise prior to quantitative analysis. Results of a pilot study in pigs under conditions of PLV are presented. Magn Reson Med 47:82–89, 2002. © 2002 Wiley‐Liss, Inc.