Premium
PEGylation of Chitosan Via Nitroxide‐Mediated Polymerization in Aqueous Media
Author(s) -
Darabi Ali,
GarcíaValdez Omar,
Champagne Pascale,
Cunningham Michael F.
Publication year - 2016
Publication title -
macromolecular reaction engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.37
H-Index - 32
eISSN - 1862-8338
pISSN - 1862-832X
DOI - 10.1002/mren.201500024
Subject(s) - polymer chemistry , macromonomer , nitroxide mediated radical polymerization , copolymer , glycidyl methacrylate , pegylation , polymerization , methacrylate , grafting , chemistry , materials science , radical polymerization , styrene , polyethylene glycol , organic chemistry , polymer
The PEGlytation of CTS with poly(poly(ethyleneglycol) methyl ether methacrylate‐co‐styrene), poly(PEGMA‐co‐S), via nitroxide‐mediated polymerization (NMP) using both grafting to and from approaches has been performed. To conduct the PEGylation of CTS via grafting to, CTS was first functionalized with glycidyl methacrylate (GMA) yielding CTS‐ g ‐GMA macromer. Poly(PEGMA‐co‐S), synthesized via NMP, was then grafted to the CTS‐ g ‐GMA. For PEGylation via grafting from, CTS‐ g ‐GMA was first converted into a macroalkoxyamine using an SG1‐based alkoxyamine. Graft copolymerization of PEGMA‐co‐S was then performed. The syntheses of CTS‐ g ‐GMA‐poly(PEGMA‐co‐S) were confirmed by 1 H NMR and TGA.