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Characterization of the Network Structure of PEG Diacrylate Hydrogels Formed in the Presence of N‐Vinyl Pyrrolidone
Author(s) -
Lee ChuYi,
Teymour Fouad,
Camastral Heinz,
Tirelli Nicola,
Hubbell Jeffrey A.,
Elbert Donald L.,
Papavasiliou Georgia
Publication year - 2014
Publication title -
macromolecular reaction engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.37
H-Index - 32
eISSN - 1862-8338
pISSN - 1862-832X
DOI - 10.1002/mren.201300166
Subject(s) - polymer chemistry , photopolymer , self healing hydrogels , acrylic acid , radical polymerization , acrylate , polymerization , peg ratio , chemistry , hydrolysis , 2 pyrrolidone , copolymer , chemical engineering , polymer , organic chemistry , finance , economics , engineering
PEGDA hydrogels copolymerized with NVP using free‐radical photopolymerization are used in biomedical applications. These networks consist of a poly(acrylate‐ co ‐vinyl pyrrolidone) backbone crosslinked with PEG chains whose crosslink density is dependent on the backbone molecular weight and composition. Insight into the network structure and characterization of the backbone molecular weight and composition is achieved by considering hydrogel degradation through ester bond hydrolysis resulting in the release of PEG and poly(acrylic acid‐ co ‐vinyl pyrrolidone). A model is developed to determine the influence of kinetic constants and phenomena on the backbone formation and is compared to experimental data. Results indicate that the backbone molecular weight is related to the amount of NVP and unaffected by polymerization time.