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Application of the Numerical Fractionation Approach to the Design of Biofunctional PEG Hydrogel Membranes
Author(s) -
Kizilel Riza,
Kizilel Seda
Publication year - 2012
Publication title -
macromolecular reaction engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.37
H-Index - 32
eISSN - 1862-8338
pISSN - 1862-832X
DOI - 10.1002/mren.201100073
Subject(s) - peg ratio , membrane , fractionation , materials science , chemical engineering , polymer science , chemistry , polymer chemistry , chromatography , engineering , business , biochemistry , finance
A mathematical model is described for surface‐initiated photopolymerization of PEG‐DA forming crosslinked biofunctional PEG hydrogel membranes based on the NF technique. The model includes an additional monomer with biological functionality, which is a common experimental strategy for the design of ECM mimics in tissue engineering in order to direct signaling pathways, and considers concentration‐dependent VP propagation and reaction diffusion termination. The influence of these features on the crosslink density of the soluble and gel phases, the progression through gelation, sol/gel fraction, and molecular weight distribution of biofunctional PEG hydrogel are studied using the NF model. This model may be useful for specific applications of tissue engineering.