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IZUMO family member 3, IZUMO3, is involved in male fertility through the acrosome formation
Author(s) -
Inoue Naokazu,
Satouh Yuhkoh,
Wada Ikuo
Publication year - 2021
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.23520
Subject(s) - acrosome , biology , spermiogenesis , biogenesis , microbiology and biotechnology , acrosome reaction , andrology , genetics , sperm , gene , nucleus , medicine
Many factors are involved in acrosome biogenesis in order for appropriate acrosome formation to occur. Here, we demonstrate that IZUMO family member 3, IZUMO3, plays an important role in acrosome biogenesis, as proven by gene disruption experiments. A loss of IZUMO3 in round spermatids affects acrosomal granule positioning due to lack of acrosomal granule contact with the inner acrosomal membrane, leading to the formation of grossly malformed spermatozoa associated with male subfertility. Thus, we suggest that mammalian spermiogenesis needs an elaborate acrosome biogenesis through IZUMO3 involvement.