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Cytokines and pregnancy: Potential regulation by histone deacetylases
Author(s) -
Munro Sheryl K.,
Balakrishnan Biju,
Lissaman Abbey C.,
Gujral Palak,
Ponnampalam Anna P.
Publication year - 2021
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.23430
Subject(s) - epigenetics , biology , proinflammatory cytokine , histone , acetylation , microbiology and biotechnology , regulation of gene expression , regulator , cancer research , immunology , genetics , inflammation , gene
Cytokines are important regulators of pregnancy and parturition. Aberrant expression of proinflammatory cytokines during pregnancy contributes towards preterm labor, pre‐eclampsia, and gestational diabetes mellitus. The regulation of cytokine expression in human cells is highly complex, involving interactions between environment, transcription factors, and feedback mechanisms. Recent developments in epigenetic research have made tremendous advancements in exploring histone modifications as a key epigenetic regulator of cytokine expression and the effect of their signaling molecules on various organ systems in the human body. Histone acetylation and subsequent deacetylation by histone deacetylases (HDACs) are major epigenetic regulators of protein expression in the human body. The expression of various proinflammatory cytokines, their role in normal and abnormal pregnancy, and their epigenetic regulation via HDACs will be discussed in this review.