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Maternally expressed miR‐379/miR‐544 cluster is dispensable for testicular development and spermatogenesis in mice
Author(s) -
Cao Congcong,
Wen Yujiao,
Dong Juan,
Wang Xiaoli,
Qin Weibing,
Huang Xunbin,
Yuan Shuiqiao
Publication year - 2018
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.22957
Subject(s) - research center , china , biology , reproductive system , center (category theory) , library science , medicine , political science , pathology , computer science , law , chemistry , anatomy , crystallography
Increasing lines of evidence suggest that miRNAs are closely related to spermatogenesis and male infertility which has aroused widespread concerns.The miR-379/miR-544 locus is the largest known placental mammal-specific miRNA cluster, whose 24 miRNA genes are expressed only from the maternal allele, and located within the high conservation of the imprinted Dlk1â€"Dio3 region.A correct dosage of imprinted genes encoded at the mouse Dlk1-Dio3 genomic interval is essential for embryonic growth and postnatal survival, as well as for muscle growth, skeletal, and neuronal development. However, whether the miR-379/miR-544 cluster at imprinted Dlk1-Dio3 region contributes to testicular development and spermatogenesis remains elusive. Here, we report that genetically inactivation of miR-379/544 cluster in mice does not exhibit any spermatogenic defects. Our data suggest maternally imprinted miR-379/544 cluster is dispensable for testicular development and spermatogenesis in mice. This article is protected by copyright. All rights reserved.