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The DNA methylation status of genes encoding Matrix metalloproteinases and tissue inhibitors of Matrix metalloproteinases in endometriosis
Author(s) -
Tang Longying,
Xiang Yuqian,
Zhou Yaohua,
Mu Jian,
Zai Meiqing,
Xing Qinghe,
Zhao Xinzhi,
He Lin,
Wang Lei,
Dong Xi,
Li Qiaoli
Publication year - 2018
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.22931
Subject(s) - matrix metalloproteinase , endometriosis , biology , mmp2 , dna methylation , gene , mmp3 , methylation , cancer research , mmp9 , promoter , gene expression , medicine , genetics , downregulation and upregulation
Endometriosis is a benign disease, with malignant properties. A necessary step in the progression of endometriosis is tissue remodeling, which is coordinated by the activities of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs). This study evaluated the regulation of abnormal MMP and TIMP gene expression during endometriosis. Among the two genes families, promoter regions of MMP2 , MMP3 , MMP7 , TIMP3 , and TIMP4 were significantly altered in proliferative‐phase endometriotic lesions compared to menstrual cycle‐matched eutopic tissue from endometriosis‐free women. In addition, a negative correlation was found between the DNA methylation status of the promoter region and transcript abundance of MMP2 . Our findings suggest that changes in DNA methylation at the promoter region of MMP2 could underlie the changes in its expression in the ectopic endometria from patients with endometriosis.