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Novel agents for sperm purification, sorting, and imaging
Author(s) -
Feugang Jean M.
Publication year - 2017
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.22831
Subject(s) - biology , sperm , fertility , semen , human fertilization , andrology , selection (genetic algorithm) , sperm quality , genetics , population , computer science , artificial intelligence , medicine , demography , sociology
The stringent selection of viable spermatozoa ensures the transmission of high‐quality genetic material to the egg during fertilization. Sperm heterogeneity within or between ejaculates and between males obliges varied post‐collection handling of semen to assure satisfactory fertility rates. The current techniques used to assess sperm generally detect non‐viable and non‐fertilizing gametes in the ejaculate, but do not permit the investigation of semen for improved fertility outcomes. Advances in technology, however, have spurred the search for new approaches to enrich semen with high‐quality spermatozoa and to track intra‐uterine sperm migration. This review highlights the current and future methodologies used for sperm labeling, selection, tracking, and imaging, with specific emphasis on the recent influence of nanotechnology.