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Function and regulation of microRNA‐31 in development and disease
Author(s) -
Stepicheva Nadezda A.,
Song Jia L.
Publication year - 2016
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.22678
Subject(s) - biology , microrna , epigenetics , regulation of gene expression , cellular differentiation , transcriptional regulation , microbiology and biotechnology , dna methylation , transcription factor , regulator , genetics , gene , gene expression
SUMMARY MicroRNAs (miRNAs) are small noncoding RNAs that orchestrate numerous cellular processes both under normal physiological conditions as well as in diseases. This review summarizes the functional roles and transcriptional regulation of the highly evolutionarily conserved miRNA, microRNA‐31 (miR‐31). miR‐31 is an important regulator of embryonic implantation, development, bone and muscle homeostasis, and immune system function. Its own regulation is disrupted during the onset and progression of cancer and autoimmune disorders such as psoriasis and systemic lupus erythematosus. Limited studies suggest that miR‐31 is transcriptionally regulated by epigenetics, such as methylation and acetylation, as well as by a number of transcription factors. Overall, miR‐31 regulates diverse cellular and developmental processes by targeting genes involved in cell proliferation, apoptosis, cell differentiation, and cell motility. Mol. Reprod. Dev. 83: 654–674, 2016 © 2016 Wiley Periodicals, Inc .