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Molecular Reproduction & Development Volume 83, Issue 2, February 2016 cover image
Publication year - 2016
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.22542
Subject(s) - biology , blastocyst , zona pellucida , embryo , hatching , embryonic stem cell , embryogenesis , microbiology and biotechnology , andrology , anatomy , genetics , oocyte , gene , ecology , medicine
The first lineage determination is an essential embryonic event in mammalian development that defines the precursors of the embryo proper from the extraembryonic tissue. Cui et al. (this issue) identify one factor that is critical for this lineage‐determination process, which normally results in the segregated expression of the embryonic marker POU5F1 (red) and the extraembryonic marker CDX2 (green) in different cells of the blastocyst. This can be seen here in a Day‐3.5 mouse embryo, counterstained for nuclei (blue). Two cells can be seen beginning the process of hatching from the zona pellucida, which is required for successful implantation.