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Molecular Reproduction & Development Volume 82, Issue 4, April 2015 cover image
Publication year - 2015
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.22394
Subject(s) - biology , oocyte , reactive oxygen species , glutathione , hydrogen peroxide , microbiology and biotechnology , mitochondrion , reproduction , citric acid cycle , follicle , biochemistry , embryo , metabolism , endocrinology , ecology , enzyme
Oocytes cultured with the common media supplements follicle‐stimulating hormone (FSH) and bone morphogenic protein 15 (BMP15) display different metabolic profiles. Sutton‐McDowall et al. (this issue) found that BMP15, an oocyte‐secreted growth factor, promotes more uniform localization of active mitochondria (represented here by Mitotracker Red in red) and increased tricarboxylic acid cycle activity. In comparison, FSH decreases reduced glutathione (an anti‐oxidant, represented here by monochlorobimane in blue) and reactive oxygen species (hydrogen peroxide, represented here by peroxyfluoro 1 in green) levels within the oocyte.