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Metabolomics fingerprinting of the human seminal plasma of asthenozoospermic patients
Author(s) -
Gilany Kambiz,
MoazeniPourasil Roudabeh Sadat,
Jafarzadeh Naser,
SavadiShiraz Elham
Publication year - 2014
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.22284
Subject(s) - metabolome , asthenozoospermia , biology , metabolomics , male infertility , infertility , chemometrics , semen , reproductive medicine , fertility , human plasma , andrology , genetics , chromatography , bioinformatics , pregnancy , medicine , chemistry , population , environmental health
SUMMARY It is estimated that 20% of couples are infertile, and half of these infertility cases are linked to men. One of conditions that can affect male fertility is asthenozoospermia. We applied Raman spectroscopy to the analysis of the metabolome of the human seminal plasma, and used chemometrics on the patterns of Raman spectra obtained. Significant changes were observed in the metabolome of the human seminal plasma of asthenozoospermic patients. Mol. Reprod. Dev. 81: 84–86, 2014. © 2013 Wiley Periodicals, Inc .