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Extrinsic and intrinsic control of germ cell proliferation in Caenorhabditis elegans
Author(s) -
Waters Katherine A.,
Reinke Valerie
Publication year - 2011
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.21289
Subject(s) - biology , caenorhabditis elegans , microbiology and biotechnology , context (archaeology) , germ cell , mitosis , stem cell , developmental biology , cellular differentiation , model organism , genetics , gene , paleontology
The germ cells of Caenorhabditis elegans serve as a useful model to study the balance between proliferation and differentiation within the context of development and changing environmental signals experienced by the animal. Germ cells adjacent to a stem cell niche in the distal region of the gonad retain the capacity to divide during adulthood, making them unique from other cells in the organism. We will highlight recent advances in our understanding of mechanisms that control proliferation, as well as the signaling pathways involved in promoting mitosis at the expense of differentiation. Mol. Reprod. Dev. 78:151–160, 2011. © 2011 Wiley‐Liss, Inc.