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Molecular Reproduction & Development: Volume 77, Issue 6, Cover image
Publication year - 2010
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.21196
Subject(s) - biology , sonic hedgehog , cortex (anatomy) , adrenal cortex , medulla , endocrinology , dapi , medicine , hedgehog , microbiology and biotechnology , genetics , neuroscience , signal transduction , apoptosis
This adrenal section shown was taken from a 1 year‐old mouse lacking Sonic hedgehog (Shh) in the steroidogenic factor‐positive adrenal cortical cells during fetal life. Lack of Shh did not affect formation of the cortex (magenta, positive for 3beta‐HSD) and medulla (green, positive for tyrosine hydroxylase). However, the mutant adrenal cortex underwent hypoplasia and hypertrophy with age. The section was counterstained with the nuclear dye DAPI (blue). See the accompanying review by Huang and Yao in this issue.