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Molecular Reproduction & Development: Volume 76, Issue 12
Publication year - 2009
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.21121
Subject(s) - trophoblast , biology , decidua , dapi , reproduction , cytokeratin , placenta , microbiology and biotechnology , andrology , epidermal growth factor , phenotype , fetus , receptor , immunology , pregnancy , gene , genetics , immunohistochemistry , staining , medicine
Heparin‐binding EGF‐like growth factor (HBEGF) at the fetal‐maternal interface in the human placenta. Extravillous trophoblast cells, marked by cytokeratin 7 (red), invade interstitially into the uterine decidua. Trophoblast and some resident uterine cells produce HBEGF (green), which stimulates trophoblast differentiation to an invasive phenotype and limits cell death during gestation. Nuclei are counterstained with DAPI (blue). See the accompanying article by Jessmon et al. in this issue.