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In vivo expression of interferon tau mRNA by the embryonic trophoblast and uterine concentrations of interferon tau protein during early pregnancy in the cow
Author(s) -
Robinson R.S.,
Fray M.D.,
Wathes D.C.,
Lamming G.E.,
Mann G.E.
Publication year - 2006
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.20431
Subject(s) - trophoblast , biology , interferon , embryo , messenger rna , andrology , interferon gamma , embryogenesis , downregulation and upregulation , medicine , endocrinology , pregnancy , placenta , immunology , fetus , cytokine , microbiology and biotechnology , gene , genetics
In this study, we have measured uterine concentrations of interferon tau and intensity of embryonic interferon tau mRNA expression between day 14 and 18 in cows. While interferon tau concentrations rose dramatically ( P < 0.001) from day 14 to 18, there was no significant increase in the intensity of expression of interferon tau mRNA by the trophoblast. When results were analyzed on the basis of embryo size, well elongated embryos (>10 cm) produced significantly ( P < 0.001) more interferon tau than smaller embryos but showed similar levels of interferon tau mRNA expression. These results demonstrate that the increase in interferon tau concentrations responsible for the maternal recognition of pregnancy results from the increase in embryo size during elongation and not from any upregulation of mRNA expression. Mol. Reprod. Dev. © 2006 Wiley‐Liss, Inc.