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Expression of Serpinb6 serpins in germ and somatic cells of mouse gonads
Author(s) -
Charron Yves,
Madani Rime,
Nef Serge,
Combepine Chantal,
Govin Jérôme,
Khochbin Saadi,
Vassalli JeanDominique
Publication year - 2006
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.20385
Subject(s) - biology , somatic cell , gametogenesis , gonad , serpin , germ plasm , germline , germ , germ line development , germ cell , sexual differentiation , embryo , microbiology and biotechnology , serine protease , genetics , embryonic stem cell , embryogenesis , endocrinology , protease , gene , biochemistry , enzyme
The serpin superfamily of serine protease inhibitors is implicated in the regulation of numerous physiological processes. In mice, Spi3/Serpinb6 has a broad tissue distribution. We have investigated the expression of Serpinb6 family members in embryonic and adult gonads. In male and female mice, Spi3/Serpinb6 and NK13/Serpinb6b were expressed in developing gonads and in both somatic and germ cells of adult gonads. By contrast, gonadal expression of Spi3C/Serpinb6c was sexually dimorphic and restricted to male germ cells and female somatic cells. These observations raise the question of the possible role(s) of the Serpinb6 family members in gonad development, gametogenesis, and/or fertilization. Mol. Reprod. Dev. © 2005 Wiley‐Liss, Inc.