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Diversification of CDK11 transcripts during chicken testis development and regression
Author(s) -
Francone Victor P.,
Mezquita Jovita
Publication year - 2005
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.20355
Subject(s) - biology , polyadenylation , rna splicing , three prime untranslated region , exon , alternative splicing , untranslated region , transcription (linguistics) , kinase , genetics , microbiology and biotechnology , messenger rna , rna , gene , linguistics , philosophy
CDK11 (cyclin‐dependent kinase 11, formerly known as PITSLRE) is a serine/threonine kinase that associates with the cyclin L2 regulatory partner. CDK11 catalytic activity has been associated with apoptosis, transcription, and RNA processing. Here, we identify novel chicken testis CDK11 transcripts that differ in their 5′UTR, 3′UTR, splicing of the exon 6, and polyadenylation. We have also characterized the differential expression of CDK11 in somatic tissues, during testis development and upon testicular regression by diethylstilbestrol (DES) treatment. The heterogeneity of CDK11 transcripts presented in this study suggests new possibilities for post‐transcriptional regulation. Mol. Reprod. Dev. © 2005 Wiley‐Liss, Inc.