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Leukemia inhibitory factor, LIF receptor, and gp130 in the mouse uterus during early pregnancy
Author(s) -
Yang ZengMing,
Le SuPing,
Chen DongBao,
Cota Juan,
Siero Valentina,
Yasukawa Kiyoshi,
Harper Michael J. K.
Publication year - 1995
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.1080420406
Subject(s) - leukemia inhibitory factor , uterus , glycoprotein 130 , biology , blastocyst , leukemia inhibitory factor receptor , receptor , pregnancy , endocrinology , medicine , andrology , embryo , embryogenesis , microbiology and biotechnology , signal transduction , biochemistry , embryonic stem cell , stat3 , genetics , gene
Leukemia inhibitory factor (LIF) has been shown to play an important role in the implantation of mouse blastocysts. The present study was designed to investigate the changes of LIF protein, LIF receptor, and gp 130 in the mouse uterus during the early pregnancy. LIF protein and LIF receptor were at high levels in the mouse uterus near the time of ovulation and on day 4 of pregnancy. gp 130 was highest on days 3 and 4 of pregnancy. Both LIF receptor and gp 130 showed strong staining in the stroma of the day 5 uterus, at a time when LIF protein was low. The presence of LIF receptor and gp 130 in the luminal epithelium on day 4 and in the stroma on day 5 may indicate the site of the high affinity LIF receptor. The coexistence of a high level of LIF protein, LIF receptor, and gp 130 in the day 4 uterus is consistent with the previously observed high level of uterine LIF mRNA on the same day and the importance of LIF for the blastocyst implantation in mouse. © 1995 wiley‐Liss, Inc.