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Potential mechanisms regulating the extracellular activities of basic fibroblast growth factor (FGF‐2)
Author(s) -
Baird Andrew
Publication year - 1994
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.1080390108
Subject(s) - fibroblast growth factor , biology , angiogenesis , microbiology and biotechnology , growth factor , extracellular , fibroblast , cell growth , fgf1 , basic fibroblast growth factor , cell , fibroblast growth factor receptor , cell culture , cancer research , genetics , receptor
Basic fibroblast growth factor (FGF‐2) is nearly ubiquitous in its distribution, leading numerous investigators to propose that there must exist highly specific mechanisms to regulate its bioavailability. Moreover, in each of the tissues where it can be localized, numerous cells are its potential target. The identification of these mechanisms could serve as an important step in developing novel strategies to inhibit FGF action. It could be possible to block such FGF‐dependent activities as angiogenesis, tumor growth, reproduction, and selected diseases of cell proliferation. Over the course of the past several years, we have attempted to describe some of the processes that might regulate a target cell's ability to activate FGF‐2 in its local milieu. © 1994 Wiley‐Liss, Inc.