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Functional analysis of the human IGF‐I gene promoters
Author(s) -
Steenbergh P. H.,
Jansen E.,
Van Schaik F. M. A.,
Sussenbach J. S.
Publication year - 1993
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.1080350408
Subject(s) - promoter , biology , gene , exon , promoter activity , transfection , genetics , microbiology and biotechnology , gene expression
The two putative promoter regions of the human insulin‐like growth factor‐I (IGF‐I) gene, located upstream of the two alternatively used leader exons 1 and 2, were tested for promoter activity in transient transfection assays. Both regions were shown to possess promoter activity. The results further indicate cell‐type‐specific regulation of the activities of the two promoters in endogenously IGF‐I producing human cell lines of different origin. © 1993 Wiley‐Liss, Inc.