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Stage and lineage‐regulated expression of two HSP 90 transcripts during mouse germ cell differentiation and embryogenesis
Author(s) -
Gruppi Carol M.,
Zakeri Zahra F.,
Wolgemuth Debra J.
Publication year - 1991
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.1080280302
Subject(s) - biology , embryogenesis , lineage (genetic) , germ cell , embryo , microbiology and biotechnology , germ , cellular differentiation , germ layer , genetics , embryonic stem cell , gene , induced pluripotent stem cell
The expression of members of the heat shock protein 90 ( hsp 90) gene family during testicular and embryonic development was investigated. Two different hsp 90 transcripts were detected in RNA from mouse testis, approximately 3.2 kb and 2.9 kb in size, and were shown to exhibit cellular and developmental stage specificity of expression. The larger, more abundant transcript was expressed at high levels in the germinal compartment of the testis, particularly in germ cells in meiotic prophase. The smaller hsp 90 transcript was expressed predominantly in the somatic compartment of the testis. Expression of the two hsp 90 transcripts was observed in testes of other species, suggesting an important role for hsp 90 in mammalian testicular function. In addition, expression of both hsp 90 transcripts was detected in the embryonic and extra‐embryonic compartments of mid‐gestation embryos.