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Protamine–histone replacement and DNA replication in the male mouse pronucleus
Author(s) -
chev Stefan,
Tsanev Roumen
Publication year - 1990
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.1080250113
Subject(s) - biology , protamine , pronucleus , histone , dna replication , male pronucleus , dna , thymidine , microbiology and biotechnology , replication (statistics) , genetics , zygote , biochemistry , virology , embryo , embryogenesis , heparin
The protamine to histone replacement in fertilized mouse eggs was studied by using antibodies to these proteins. Its course was followed with respect to DNA replication by autoradiography of 3 H‐thymidine‐labeled fertilized eggs. It was found that protamines were replaced by histones before the onset of DNA replication.