Premium
Role of apoptosis and Fas/FasL system in the oogenesis of the spotted ray Torpedo marmorata
Author(s) -
Loredana Ricchiari,
Barbara D'onghia,
Annamaria Liguoro,
Stefania Tammaro,
Maria Motta Chiara,
Silvana Filosa,
Piero Andreuccetti,
Marina Prisco
Publication year - 2003
Publication title -
molecular reproduction and development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 105
eISSN - 1098-2795
pISSN - 1040-452X
DOI - 10.1002/mrd.10324
Subject(s) - biology , oocyte , oogenesis , apoptosis , germ cell , tunel assay , microbiology and biotechnology , fas ligand , embryo , gonad , andrology , medicine , endocrinology , zoology , programmed cell death , gene , genetics
In the present paper we investigated the role played by apoptosis during oogenesis in the cartilagineous fish Torpedo marmorata . TEM, TUNEL and immunohistochemical techniques were employed to specifically reveal morphological and biochemical hallmarks of apoptosis in specimens from birth to sexual maturity. Data obtained demonstrate that apoptosis occurs in prefollicular oocyte selection, in maintaining the homeostasis of granulosa in healthy growing oocyte and in resorbing atretic follicles. In this respect, the involvement of apoptosis in Torpedo marmorata oogenesis closely parallels that found in mammals, thus confirming that strategies of germ cell selection among vertebrates have been evolutively preserved. Mol. Reprod. Dev. 66: 54–59, 2003. © 2003 Wiley‐Liss, Inc.