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Assignment of the 13 C and 15 N NMR spectra of the antitumour antibiotic streptonigrin
Author(s) -
Anderberg Pia I.,
Luck Ian J.,
Harding Margaret M.
Publication year - 2002
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.997
Subject(s) - chemistry , heteronuclear single quantum coherence spectroscopy , dept , carbon 13 nmr , stereochemistry , nmr spectra database , spectral line , nuclear magnetic resonance spectroscopy , physics , astronomy
The assignments of the two pyridyl nitrogens and two amino nitrogens in the antitumour antibiotic streptonigrin, and all carbon resonances, were determined by 15 N (HSQC, HMBC) and 13 C (HSQC, HMBC) NMR techniques. These data provide useful probes for determination of the site(s) of metal complexation in the drug, which are important in the mechanism of antitumour activity. Copyright © 2002 John Wiley & Sons, Ltd.