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Reorientational dynamics, hydrogen bonding and hydrophilicity of X‐ray contrast agents in solution
Author(s) -
van de Bruck Michael,
Dölle Andreas,
Michl Günter,
Radüchel Bernd
Publication year - 2001
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.936
Subject(s) - chemistry , iohexol , iopamidol , iopromide , hydrogen bond , molecular dynamics , relaxation (psychology) , aqueous solution , analytical chemistry (journal) , nuclear magnetic resonance , computational chemistry , molecule , organic chemistry , contrast medium , renal function , medicine , psychology , social psychology , biochemistry , physics , radiology
In order to probe the hydrophilic and lipophilic properties of iodinated X‐ray contrast agents, a new parameter was introduced, the relative reduced molecular correlation time of reorientational motion. Therefore, the viscosities and 13 C spin–lattice relaxation times of the five contrast agents iopromide, iohexol, iopamidol, iotetrol and N ‐acetyliotetrol in their solutions with dimethylsulfoxide, water and methanol were measured. From these data the relative reduced molecular correlation times were evaluated, and a relation between these correlation times and measured water/butanol partition coefficients [log( P ) values] could be established. The order for the relative reduced molecular correlation times is: iopromide > iopamidol > iohexol > N ‐acetyliotetrol > iotetrol. When subdividing the contrast agents into classes of structurally similar compounds, the same order was observed for the log(P) values, namely iopromide > iopamidol > iohexol. Copyright © 2001 John Wiley & Sons, Ltd.
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