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Survey of NMR experiments for the determination of n J (C,H) heteronuclear coupling constants in small molecules
Author(s) -
Marquez Brian L.,
Gerwick William H.,
Thomas Williamson R.
Publication year - 2001
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.902
Subject(s) - heteronuclear molecule , chemistry , coupling constant , heteronuclear single quantum coherence spectroscopy , analytical chemistry (journal) , hyperpolarizability , molecule , computational chemistry , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , nuclear magnetic resonance spectroscopy , physics , polarizability , organic chemistry , particle physics
A survey of heteronuclear correlation experiments for the measurement of heteronuclear coupling constants is presented. The purpose of this survey is to evaluate several recent experiments for measuring n J (C,H) ( n = 2, 3) couplings in one comprehensive review. Ten experiments are presented and evaluated relative to one another in terms of experimental usability, ease of data interpretation and number of usable correlations. The experiments compared in this survey are the sensitivity‐improved hetero‐( ω 1 )‐half‐filtered TOCSY (HETLOC), carbon‐sorted HETLOC (HSQC‐HECADE), coupled/decoupled HSQC‐TOCSY, GSQMBC, HSQMBC, G‐BIRD R,X ‐HSQMBC, J ‐resolved HMBC‐2, J ‐IMPEACH‐MBC and methods for extracting heteronuclear coupling constants from gradient‐selected variants of the magnitude‐mode and phase‐sensitive HMBC. The plant alkaloid strychnine was used as a model compound for this study. Copyright © 2001 John Wiley & Sons, Ltd.