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Preferential solvation of a tetrapeptide by trifluoroethanol as studied by intermolecular NOE
Author(s) -
Díaz M. Dolores,
Berger Stefan
Publication year - 2001
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.859
Subject(s) - homonuclear molecule , chemistry , heteronuclear molecule , tetrapeptide , solvation , intermolecular force , peptide , crystallography , stereochemistry , nuclear magnetic resonance spectroscopy , molecule , organic chemistry , biochemistry
Homonuclear and heteronuclear intermolecular NOE measurements were applied to study the solvation of a short model tetrapeptide, NAc‐Ser‐Phe‐Val‐Gly‐OMe, dissolved in water, in trifluoroethanol (TFE) and in mixtures of both. Site specificity of homonuclear NOEs between water and different protons of the peptide was proved. Preferential solvation of the peptide by TFE in water–TFE mixtures was demonstrated by a significant decrease in water–peptide interaction and a concomitant buildup of heteronuclear NOE between the fluorine atoms of TFE and the peptide. Copyright © 2001 John Wiley & Sons, Ltd.