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Assignment of the 1 H and 13 C NMR spectra, sequence and conformation of the synthetic pentasaccharide SanOrg34006 and its precursors
Author(s) -
Bootsma Judica,
Wagenaars Gerard,
Dreef Erik,
Hout Floris,
Kellenbach Edwin
Publication year - 2001
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.836
Subject(s) - chemistry , heteronuclear molecule , moiety , coupling constant , stereochemistry , chemical shift , sequence (biology) , proton , molecule , pulse sequence , nmr spectra database , nuclear magnetic resonance spectroscopy , proton nmr , homonuclear molecule , spectral line , crystallography , organic chemistry , nuclear magnetic resonance , biochemistry , physics , particle physics , astronomy , quantum mechanics
Proton and carbon chemical shift data and proton–proton coupling constants of the synthetic antithrombotic pentasaccharide SanOrg34006 and its synthetic precursors are reported. Long‐range heteronuclear correlation experiments allow the determination of the substitution pattern of the protecting groups in the precursor molecules. Also, the sequence of the oligosaccharide was confirmed this way. The conformation of the α‐ L ‐iduronic acid moiety was studied by the analysis of the 3 J ( 1 H, 1 H) coupling constants. Copyright © 2001 John Wiley & Sons, Ltd.