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Clean adiabatic TOCSYs
Author(s) -
Kupče Ē.,
Hiller W.
Publication year - 2001
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.831
Subject(s) - adiabatic process , mixing (physics) , chemistry , relaxation (psychology) , limit (mathematics) , gaussian , sensitivity (control systems) , diffusion , spin (aerodynamics) , phase (matter) , interference (communication) , thermodynamics , quantum mechanics , computational chemistry , physics , organic chemistry , mathematical analysis , psychology , social psychology , channel (broadcasting) , mathematics , electrical engineering , electronic engineering , engineering
Abstract Various adiabatic mixing schemes are explored using numerical simulations with the aim of finding suitable mixing sequences for fast rotating samples with relatively wide resonances and poorly resolved J ‐couplings, such as proteins or resin‐bound products of solid‐phase synthesis. It is shown both experimentally and by simulations that WURST‐2 mixing scheme provides the best sensitivity and the lowest interference from cross‐relaxation effects in the spin diffusion limit. For medium‐sized molecules, WURST‐1, constant adiabaticity Gaussian and hyperbolic secant are the possible alternatives. Copyright © 2001 John Wiley & Sons, Ltd.