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Discrimination of stereoisomers by one‐dimensional 13 C NMR: All 16 stereoisomers of 4‐hydroxy‐α‐tocopherol resolved
Author(s) -
Lankhorst Peter P.,
Duchateau Alexander L. L.,
Netscher Thomas
Publication year - 2021
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.5202
Subject(s) - chemistry , tocopherol , stereochemistry , nuclear magnetic resonance , organic chemistry , vitamin e , antioxidant , physics
All 16 resolved! A vitamin E‐derived compound containing four chiral centers is the first example where all stereoisomers, that is, eight diastereomeric pairs of enantiomers, could be discriminated in a single NMR run. Measurement at 176 MHz in the presence of Pirkle's alcohol as a chiral solvating agent is a relatively robust, simple, easy‐to‐set‐up, and fast method.