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Benefits of time‐resolved nonuniform sampling in reaction monitoring: The case of aza‐Michael addition of benzylamine and acrylamide
Author(s) -
Gołowicz Dariusz,
Kaźmierczak Magdalena,
Kazimierczuk Krzysztof
Publication year - 2021
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.5105
Subject(s) - benzylamine , chemistry , spectral line , sampling (signal processing) , michael reaction , acrylamide , signal (programming language) , analytical chemistry (journal) , organic chemistry , catalysis , optics , polymer , computer science , copolymer , physics , detector , astronomy , programming language
Monitoring of chemical reactions is best carried out using methods that sample the test object at a rate greater than the time scale of the processes taking place. The recently proposed time‐resolved nonuniform sampling (TR‐NUS) method allows the use of two‐dimensional (2D) nuclear magnetic resonance (NMR) spectra for this purpose and provides a time resolution equivalent to that achievable using one‐dimensional spectra. Herein, we show that TR‐NUS acquired data eliminates 2D spectral line disturbances and enables more accurate signal integration and kinetics conclusions. The considerations are exemplified with a seemingly simple aza‐Michael reaction of benzylamine and acrylamide. Surprisingly, the product identification is possible only using 2D spectra, although credible monitoring requires TR‐NUS.