Structure elucidation of a new triterpene from  Inonotus obliquus | Zendy

Park Sangmin | Zendy; Shin Hyeji | Zendy; Park Dawon | Zendy; Kim Hyunwoo | Zendy; Byun Youngjoo | Zendy; Lee Ki Yong | Zendy

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Structure elucidation of a new triterpene from Inonotus obliquus

Author(s) -

Park Sangmin,

Shin Hyeji,

Park Dawon,

Kim Hyunwoo,

Byun Youngjoo,

Lee Ki Yong

Publication year - 2021

Publication title -

magnetic resonance in chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.483

H-Index - 72

eISSN - 1097-458X

pISSN - 0749-1581

DOI - 10.1002/mrc.5102

Subject(s) - inonotus obliquus , triterpene , chemistry , nitric oxide , lipopolysaccharide , fractionation , terpene , ethyl acetate , stereochemistry , biochemistry , organic chemistry , medicine , alternative medicine , pathology , endocrinology

Ethyl acetate (EtOAc) fraction of the Inonotus obliquus (Hymenochaetaceae) significantly inhibited nitric oxide production in lipopolysaccharide (LPS)–induced murine BV2 microglial cells. A new triterpene, characterized as inonotusol H ( 1 ), was isolated from the EtOAc fraction using the bioactivity‐guided fractionation together with four known triterpenes, inotodiol ( 2 ), trametenolic acid ( 3 ), inonotsutriols A ( 4 ), and inonotusol A ( 5 ). Among them, Compounds 2 – 4 significantly reduced LPS‐induced nitric oxide production to 4.5 ± 0.8%, 47.4 ± 4.4%, and 2.8 ± 1.7%, respectively, at a concentration of 30 μM.

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