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Measurement of the hydrodynamic radii of PEE‐G dendrons by diffusion spectroscopy on a benchtop NMR spectrometer
Author(s) -
McCarney Evan R.,
Breaux Carol J.,
Rendle Phillip M.
Publication year - 2020
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4997
Subject(s) - chemistry , hydrodynamic radius , dendrimer , diffusion , nuclear magnetic resonance spectroscopy , spectroscopy , analytical chemistry (journal) , radius , spectrometer , solvent , nuclear magnetic resonance , polymer , polymer chemistry , organic chemistry , thermodynamics , optics , physics , computer security , quantum mechanics , computer science , copolymer
Benchtop nuclear magnetic resonance (NMR) spectroscopy is a useful tool for the rapid determination of the self‐diffusion coefficient and the hydrodynamic radius of dendrons. The self‐diffusion coefficients of the first four generations of poly ethoxy ethyl glycinamide (PEE‐G) dendrons are measured by diffusion‐ordered spectroscopy (DOSY) on a benchtop NMR equipped with diffusion gradient coils. The hydrodynamic radii of the dendrons are calculated via the Stokes–Einstein equation. The effects of solvent and pH are determined with the hydrodynamic radius increasing with generation and decreasing upon neutralization of an acidic solution. These measurements provide valuable information for biological and pharmaceutical applications of dendrons.