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How to measure long‐range proton‐carbon coupling constants from 1 H‐selective HSQMBC experiments
Author(s) -
Saurí Josep,
Nolis Pau,
Parella Teodor
Publication year - 2020
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4928
Subject(s) - heteronuclear molecule , chemistry , coupling constant , range (aeronautics) , scalar (mathematics) , proton , carbon 13 , sign (mathematics) , molecule , computational chemistry , coupling (piping) , measure (data warehouse) , organic chemistry , nuclear physics , physics , quantum mechanics , mechanical engineering , mathematical analysis , geometry , mathematics , database , computer science , engineering , materials science , composite material
Heteronuclear long‐range scalar coupling constants ( n J CH ) are a valuable tool for solving problems in organic chemistry and are especially suited for stereochemical and configurational analyses of small molecules and natural products. This tutorial will focus on the step‐by‐step implementation of several 2D 1 H frequency selective HSQMBC experiments for the easy and accurate measurement of either the magnitude or both the magnitude and the sign of long‐range n J CH couplings. The performance of these experiments will be showcased with several scenarios in a range of different experimental conditions.