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Practical aspects of oligopeptide AAKLVFF as an alignment medium for the measurements of residual dipolar coupling of organic molecules
Author(s) -
Liu Han,
Chen Pian,
Li XiaoLu,
Sun Han,
Lei Xinxiang
Publication year - 2020
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4825
Subject(s) - oligopeptide , chemistry , residual dipolar coupling , homogeneous , coupling (piping) , dipole , residual , molecule , chemical physics , computational chemistry , combinatorial chemistry , stereochemistry , organic chemistry , peptide , statistical physics , biochemistry , physics , mechanical engineering , algorithm , computer science , engineering
Practical aspects of the oligopeptide AAKLVFF as an alignment medium are discussed, including large‐scale synthesis of the oligopeptide, detailed description of preparation of the alignment medium, and acquisition of the RDCs. The resulting orienting medium is stable and highly homogeneous with tunable alignment strength in methanol. We demonstrated its applicability on the stereochemical elucidation of two natural products, oridonin and α ‐santonin.