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Homonuclear decoupling by projection reconstruction
Author(s) -
Görling Benjamin,
Bermel Wolfgang,
Bräse Stefan,
Luy Burkhard
Publication year - 2018
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4784
Subject(s) - homonuclear molecule , heteronuclear molecule , chemistry , heteronuclear single quantum coherence spectroscopy , nuclear magnetic resonance , tilt (camera) , projection (relational algebra) , two dimensional nuclear magnetic resonance spectroscopy , molecular physics , physics , nuclear magnetic resonance spectroscopy , molecule , geometry , mathematics , algorithm , organic chemistry
Similar to J ‐resolved spectroscopy, also, heteronuclear multiple bond correlation (HMBC), heteronuclear single bond correlation (HSBC), and heteronuclear multiple quantum coherence (HMQC) types of correlation experiments result in homonuclear tilted multiplet patterns. On the example of the high‐resolution heteronuclear single bond correlation (HR‐HSBC) pulse sequence, it is shown how the tilt angle can be varied within a wide range of positive and negative values. Projection along the tilt angles in all cases results in homonuclear decoupling. Using well‐known projection reconstruction techniques, the different tilt angles can be used to reconstruct a homonuclear decoupled two‐dimensional correlation spectrum. The concept is proven and further refined by segmental projection reconstruction and the use of a clean in‐phase heteronuclear single quantum correlation (CLIP‐HSQC) spectrum with an effective zero tilt angle for further filtering. The proof of principle, its application to one‐bond coupling measurement, as well as a basic HMBC, and a detailed discussion with comparison to other homodecoupling techniques are given.