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Separating the coherence transfer from chemical shift evolution in high‐resolution pure shift COSY NMR
Author(s) -
Aguilar Juan A.,
Belda Raquel,
Gaunt Benjamin R.,
Kenwright Alan M.,
Kuprov Ilya
Publication year - 2018
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4727
Subject(s) - chemistry , heteronuclear single quantum coherence spectroscopy , limiting , spectral line , nmr spectra database , resolution (logic) , coherence (philosophical gambling strategy) , chemical shift , sampling (signal processing) , analytical chemistry (journal) , dispersion (optics) , two dimensional nuclear magnetic resonance spectroscopy , high resolution , chromatography , stereochemistry , optics , physics , computer science , engineering , mechanical engineering , quantum mechanics , artificial intelligence , detector , remote sensing , astronomy , geology
Recent developments in data sampling and processing techniques have made it possible to acquire 2‐dimensional NMR spectra of small molecules at digital resolutions in both dimensions approaching the intrinsic limitations of the equipment and sample on a realistic timescale. These developments offer the possibility of enormously increased effective resolution (peak dispersion) and the ability to effectively study samples where peak overlap was previously a limiting factor. Examples of such spectra have been produced for a number of 2‐dimensional techniques including TOCSY and HSQC. In this paper, we investigate some of the problems in applying such techniques to COSY spectra and suggest a modification to the classic experiment that alleviates some of these problems.