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Broadband homonuclear decoupled HSQMBC methods
Author(s) -
Timári István,
Kövér Katalin E.
Publication year - 2018
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4700
Subject(s) - homonuclear molecule , heteronuclear molecule , chemistry , decoupling (probability) , broadband , molecule , sensitivity (control systems) , analytical chemistry (journal) , physics , optics , organic chemistry , electronic engineering , control engineering , engineering
Long‐range heteronuclear coupling constants convey invaluable information for stereochemical and conformational analysis of molecules from synthetic and natural origin. Here, we report a real‐time Zangger‐Sterk CPMG‐HSQMBC method for the precise and direct measurement of multiple‐bond heteronuclear couplings. It is demonstrated that the real‐time acquisition strategy combined with multiple slice selective excitation can provide substantial improvement in sensitivity (or reduction of experimental time) as compared to other variants of broadband homonuclear decoupled HSQMBC methods published previously. Scope and limitations of the different strategies applied for decoupling are reviewed. Moreover, practical guidelines for the choice of the most appropriate method are also presented. Applications are given on a metal complex incorporating P‐heterocycles and two diglycosyl‐selenides for the extraction of n J ( 1 H, 31 P) and n J ( 1 H, 77 Se), respectively.