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Multiple homonuclear band‐selective decoupling NMR : Fast and unambiguous determination of diastereomeric excess
Author(s) -
Rachineni Kavitha,
Kakita Veera Mohana Rao,
Hosur Ramakrishna V.
Publication year - 2018
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4634
Subject(s) - homonuclear molecule , chemistry , diastereomer , analytical chemistry (journal) , spins , proton nmr , chromatography , nuclear magnetic resonance , stereochemistry , organic chemistry , physics , molecule , condensed matter physics
Discrimination and quantification of chiral stereoisomers have been studied by different analytical methods, and NMR has emerged as a powerful one with the advancements in pure‐shift NMR methods. In the present manuscript, an al‐F1F2‐MHOBS‐DIAG NMR method for the quantification of diastereomeric excess ratio (dr) has been proposed and demonstrated, using hesperidin and naringin mixtures. This method enables simultaneous quantification of dr at multiple resonances, in a single experiment, and it takes only 10 min to record. The present method uses spectral aliasing and thus demands only very few indirect dwell increments. Further, the measured dr values are very reliable, because we consider several spins for the quantification.