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Resolving DOSY spectra of isomers by methanol‐d 4 solvent effects
Author(s) -
Reile Indrek,
Aspers Ruud L. E. G.,
Feiters Martin C.,
Rutjes Floris P. J. T.,
Tessari Marco
Publication year - 2017
Publication title -
magnetic resonance in chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.483
H-Index - 72
eISSN - 1097-458X
pISSN - 0749-1581
DOI - 10.1002/mrc.4587
Subject(s) - chemistry , methanol , solvent , solvent effects , content (measure theory) , spectral line , organic chemistry , computational chemistry , mathematical analysis , physics , mathematics , astronomy
DOSY analysis can resolve analytes according to their molecular size, offering a complementary way to traditional 2D NMR spectroscopy in the study of chemical mixtures. Applications are, however, limited if analytes have similar shape and size, as is the case in isomer mixtures. Herein we show how solvent effects in methanol-d4, a common solvent in NMR laboratories, allow to overcome this limitation and provide increased separation of isomeric compounds. Clear NMR signal separation of eight structurally related analytes within a molecular weight (MW) range of three units is demonstrated, allowing unambiguous analysis of a mixture that would have otherwise been unsuitable for DOSY.